Breast Digital Infrared Analysis (DIRA) , a forgotten and set aside procedure.

Visita: termografiamamaria.blogspot.com (Version en Español)

Breast DIRA (previously named Thermography) already proved in the past that it´s use as an screening procedure had low specificity and high sensitive values for it to be recommended as an standard care Breast diagnosis tool .
Yet , until recently (last 5 years) active research mainly by Surgical Oncologists or Breast Surgeons have published interesting results.( Cornell NY , Addenbrooke Cambridge , Ville Marie Montreal , Taiwan and Mexico CEPREC)
FDA previous published criteria were prohibiting DIRA as well as the A.C. of Radiologists ( as an initial SCREENING TOOL)

Yet it has been cleared by the FDA approval as an adjunctive screening tool for breast cancer .( under 510 k) .

DIRA´s meaning is not an ANATOMIC or ARCHITECTURAL procedure ,it is a METABOLIC or PHYSIOLOGIC ONE so at first it ´s current recommendation should be only as a COMPLEMENTARY STUDY.

As such DIRA could help in specific scenarios, BIRADS 0,3,4 and give potential useful additional data in BIRADS5. EVEN BEFORE BIOPSY
Could aid mammogram in young,dense and breast prosthesis patients, and should be evaluated in other clinical scenarios as a Neoadyuvant Monitoring tool.
Finally as an early detecion procedure specifically in underdeveloped countries , could Triage in search of aggresive forms of the disease(T1,G2_G3). And aid Physical Exam of the Breast .
This site is dedicated to open mind Breast specialists ONLY .
¨EXPANDING OUR CURRENT COMPREHENSION, UNDERSTANDING AND APPROACH OF IMAGE AND DIAGNOSIS IN BREAST CANCER¨

miércoles, 22 de febrero de 2012

Case Number # 4. T1 easily detected

Case Number 4 .
Female 55 year of age , no family history for breast cancer .Asymptomatic Nodule detected during Gynecologic physical examination .
Conventional imaging studies were realized : Mammogram and Ultrasound.


Parenchymal Density assimetry in the Rigth Upper Quadrant of the Breast.



With architectural distorsion but no microcalcifications
and inflammatory Axillary Lymph Nodes.

Ultrasound . 1.57 irregular solid lesion , characteristically taller than its width measure.


Ultrasound : 1.57 cm irregular solid lesion characteristically taller than its graetest width measure.
Standard BIRADS diagnosis : V equivalent to 95% chance for breast cancer.
Digital Infrared Analyisis of the same patiente in its frontal view :
Rigth Breast IR assimetry : with locally augmented thermovascular network localized to the outer and upper. After the cold challenge or simuli : With a Delta Difference to surrounding tissue and to the contralateral region of 1.0 centigrades .
Termal summit of 34.8 centigrades , which is coincidental for the clinically suspicious lesion or nodule.
Close Up , local vesselss are delineated , otherwise "invisible" to the naked eye.

DIRA Score (CCan) of 103
Suspicious for malignancy because of the alternate variables (+ -)
Associated with standard diagnosis methods : Probably a low grade breast carcinoma with negative axillary lumph nodes .

Final Pathological Report :
Invasive Ductal Carcinoma Moderatley Differenciated .

Pacient was initially treated with : Quadrantectomy and Selective Sentinel Lymph Node DIssection .
  1. Sentinel Lymph Nodes were Negative.
  2. Negative Her2 neu
  3. Positive Estrogen Receptors
To this date patient is in follow up after 1.9 year after treatment.

"Digital Infrared analysis of the Breast as a complementary or adjunctive study : offered data regarding biological behaviour of the suspected lesion"

A limited lesion or disease was reconfirmed , with a low SCORE , which was locally controlled with breast preserving Surgery and selective axillary dissection ". The patient was sent then to Medical Oncology Unit and Radiotherapy for Standard Therapy.

Prospective protocols could confirm the next HYPOTHESIS :

"LOW IR-SCORE : Localized Disease - ¨Possible Negative Lymph Nodes -Negative HER2neu Status - Positive Hormonal Recpetor Status ."

Could Unify Criteria between Breast Cancer Doctors ( Surgeons , Radiologists , Medical Oncologists and Radiotherapists) :
  1. Initial Treatment Option ,
  2. Association to Lymph Node Positivity : Sentinel Lymph Node Cost Benefit Use.
  3. Predictive Values for HER 2 neu Hormonal Receptors
  4. Microvascular Density etc...
" BREAST CANCER CHARACTERISTIC INFRARED PATTERNS EXIST IN POSTMENOPAUSAL WOMEN . EMC"
(ir-Pattern)

" IF THE IR ASSYMETRY IS EVIDENT , THEN THE INFRARED IMAGE CAN BE USED AS A ADJUVANT METHOD TO BREAST PHYSICAL EXAM , SPECIALLY IN COUNTRIES WERE MAMMOGRAPHY IS NOT WIDELY AVAILABLE.
THIS WOULD DOWNSTAGE THEIR CURRENT TUMOR SIZE AVERAGE .
AND WE WOULD STILL RECOMMEND MAMOMMAGRAM AND ULTRASOUND AS THE STANDARD OF CARE FOR SMALLER LESIONS."
EMC :
(ir-Xplore)


ir Image , does not stands as a substitute for mammogram , yet the Breast Cancer as a problem is serious , the numbers do not lie and it offers as an option to be reexplored under the most strict ethical protocols. "ir Image could aid and benefit"