The Breast Thermography Journal (Digital Infrared Analysis): junio 2013

Breast Digital Infrared Analysis (DIRA) , a forgotten and set aside procedure.

Visita: termografiamamaria.blogspot.com (Version en Español)

Breast DIRA (previously named Thermography) already proved in the past that it´s use as an screening procedure had low specificity and high sensitive values for it to be recommended as an standard care Breast diagnosis tool .

Yet , until recently (last 5 years) active research mainly by Surgical Oncologists or Breast Surgeons have published interesting results.( Cornell NY , Addenbrooke Cambridge , Ville Marie Montreal , Taiwan and Mexico CEPREC)

FDA previous published criteria were prohibiting DIRA as well as the A.C. of Radiologists ( as an initial SCREENING TOOL)

Yet it has been cleared by the FDA approval as an adjunctive screening tool for breast cancer .( under 510 k) .

DIRA´s meaning is not an ANATOMIC or ARCHITECTURAL procedure ,it is a METABOLIC or PHYSIOLOGIC ONE so at first it ´s current recommendation should be only as a COMPLEMENTARY STUDY.

As such DIRA could help in specific scenarios, BIRADS 0,3,4 and give potential useful additional data in BIRADS5. EVEN BEFORE BIOPSY

Could aid mammogram in young,dense and breast prosthesis patients, and should be evaluated in other clinical scenarios as a Neoadyuvant Monitoring tool.

Finally as an early detecion procedure specifically in underdeveloped countries , could Triage in search of aggresive forms of the disease(T1,G2_G3). And aid Physical Exam of the Breast .

This site is dedicated to open mind Breast specialists ONLY .

¨EXPANDING OUR CURRENT COMPREHENSION, UNDERSTANDING AND APPROACH OF IMAGE AND DIAGNOSIS IN BREAST CANCER¨

lunes, 24 de junio de 2013

Digital Infrared Analysis of the Breast_Free and Available.

Breast Cancer ORDER is mantained by the evidence created during the last 40 years with Mammography.

Nobody denies its intrinsic value and strengths.

It is our primary language against the Common Enemy : Breast Cancer

Yet , to reach its ideal goals and current trends it involves a complicated network of :

personal ,
political ,
cultural ,
geographical and
economical interests around this sometimes regretfuly "fashion" topic.

(Specially sensitive and a super candidate for promotion and glamour.)

To affirm that ONLY mammography holds the truth is

To deny that anything else can help , and sounds to me as a MONOPOLY ...........

A scientifically based evidence of the INFRARED analysis and Behaviour of those MALIGNANT potentially MORTAL types of BREAST CANCER in my mind is not only necessary but an obligation.....for all

Since current trends will be of Tsunamic Proportions as some have already stated

.....Advanced cases in the vast majority of countries will keep on rising if we follow the same recommendations.

I do not intend to set aside Mammography ...that is not only impossible but Stupid.

I simply would like to let you know that DIRA can be useful and as time goes by , more and more examples will join , more women will be helped and an specific nich for its use will rise.

Last of all : I think that DIRA should be FREE or near to free and available only for Breast Cancer Specialists .

Have a great week------EMC

jueves, 20 de junio de 2013

Nanoparticles-Infrared Image-Excised MArgins in Breast Cancer.

Hi everybody , one of the most important problems that we as surgeons have in breast conserving surgery is being able to deliver : SAFE MARGINS.

This is generally achieved as a "BLIND" procedure and it is dependent of individual clinical and surgical expertise in order to produce negative tissue inked margins in the final pathological report , some recommend at least 1 cm of safe distance... so

QUESTION : Can we in the near Future have an available method that can help us assure this "safety" in margins ?

Recent efforts are being described that couple:

Nanoparticles associated with
CANCER SPECIFIC Antibodies
Nanoparticle excited physical properties and
It corresponding image :

Here is an example and is reference ......

I believe :

"In the near future we will have the Technology by the association of Nanoparticles , monoclonal antibodies and the digital infrared image or another physical and visual intrinsic characteristic , which :

WILL OFFER in vivo A VISUAL AID FOR THE SURGEON to produce safe margins in breast conserving surgery ."EMC

Have a great day :

(A) Schematic representation of nanoparticle communication to achieve amplified tumor targeting. Tumor-targeted signaling nanoparticles (blue) broadcast the tumor location to the receiving nanoparticles (red) present in circulation. (B) Shown are the harnessing of the biological cascade to transmit and amplify nanoparticle communication and the molecular signaling pathway between the signaling and receiving components. (C) Thermographic images of the photothermal NRs with heating. Seventy-two hours after NR or saline injection, mice were co-injected with FXIII-NWs and untargeted control-NWs, and their right flanks were broadly irradiated (top). Twenty-four hours post-irradiation, whole-animal fluorescence imaging revealed the distribution of the receiving nanoparticles (bottom). (D) Amplified tumor therapy with communicating nanoparticles. Tumor volumes following a single treatment with the communicating nanoparticle systems and controls. Reproduced with permission from ref :

von Maltzahn G, Park JH, Lin KY, Singh N, Schwöppe C, Mesters R. et al. Nanoparticles that communicate in vivo to amplify tumour targeting. Nat Mater. 2011;10:545-52

This is another example with Fluorescent propierties......

Assessing Breast Cancer Margins Ex Vivo Using Aqueous Quantum-Dot-Molecular Probes

Giang H. T. Au,¹ Wan Y. Shih,¹ Wei-Heng Shih,² Linette Mejias,³ Vanlila K. Swami,³ Kimberly Wasko,⁴ and Ari D. Brooks⁴

International Journal of Surgical Oncology
Volume 2012 (2012), Article ID 861257, 12 pages
doi:10.1155/2012/861257