Nanoparticles-Infrared Image-Excised MArgins in Breast Cancer.

Hi everybody , one of the most important problems that we as surgeons have in breast conserving surgery is being able to deliver : SAFE MARGINS.

This is generally achieved as a "BLIND" procedure and it is dependent of individual  clinical and surgical  expertise  in order to produce negative tissue inked margins in the final pathological report , some recommend at least 1 cm of safe distance... so 

QUESTION : Can we in the near Future have an available method that can help us assure this "safety" in margins ?

Recent efforts are being described that couple:

1.  Nanoparticles associated with 
2. CANCER SPECIFIC Antibodies 
3. Nanoparticle excited physical properties  and  
4. It corresponding image :

Here is an example and is reference ......

I believe : 

"In the near future we will have the Technology by the association of Nanoparticles , monoclonal antibodies and the digital infrared image or another physical and visual intrinsic characteristic , which : 

WILL OFFER in vivo A VISUAL AID FOR THE SURGEON to produce safe margins in breast  conserving surgery ."EMC

Have a great day : 

(A) Schematic representation of nanoparticle communication to achieve amplified tumor targeting. Tumor-targeted signaling nanoparticles (blue) broadcast the tumor location to the receiving nanoparticles (red) present in circulation. (B) Shown are the harnessing of the biological cascade to transmit and amplify nanoparticle communication and the molecular signaling pathway between the signaling and receiving components. (C) Thermographic images of the photothermal NRs with heating. Seventy-two hours after NR or saline injection, mice were co-injected with FXIII-NWs and untargeted control-NWs, and their right flanks were broadly irradiated (top). Twenty-four hours post-irradiation, whole-animal fluorescence imaging revealed the distribution of the receiving nanoparticles (bottom). (D) Amplified tumor therapy with communicating nanoparticles. Tumor volumes following a single treatment with the communicating nanoparticle systems and controls. Reproduced with permission from ref :

 von Maltzahn G, Park JH, Lin KY, Singh N, Schwöppe C, Mesters R. et al. Nanoparticles that communicate in vivo to amplify tumour targeting. Nat Mater. 2011;10:545-52

This is another example with Fluorescent propierties...... 

Assessing Breast Cancer Margins Ex Vivo Using Aqueous Quantum-Dot-Molecular Probes

Giang H. T. Au,¹ Wan Y. Shih,¹ Wei-Heng Shih,² Linette Mejias,³ Vanlila K. Swami,³ Kimberly Wasko,⁴ and Ari D. Brooks⁴

International Journal of Surgical Oncology
Volume 2012 (2012), Article ID 861257, 12 pages
doi:10.1155/2012/861257