Breast Digital Infrared Analysis (DIRA) , a forgotten and set aside procedure.

Visita: termografiamamaria.blogspot.com (Version en Español)

Breast DIRA (previously named Thermography) already proved in the past that it´s use as an screening procedure had low specificity and high sensitive values for it to be recommended as an standard care Breast diagnosis tool .
Yet , until recently (last 5 years) active research mainly by Surgical Oncologists or Breast Surgeons have published interesting results.( Cornell NY , Addenbrooke Cambridge , Ville Marie Montreal , Taiwan and Mexico CEPREC)
FDA previous published criteria were prohibiting DIRA as well as the A.C. of Radiologists ( as an initial SCREENING TOOL)

Yet it has been cleared by the FDA approval as an adjunctive screening tool for breast cancer .( under 510 k) .

DIRA´s meaning is not an ANATOMIC or ARCHITECTURAL procedure ,it is a METABOLIC or PHYSIOLOGIC ONE so at first it ´s current recommendation should be only as a COMPLEMENTARY STUDY.

As such DIRA could help in specific scenarios, BIRADS 0,3,4 and give potential useful additional data in BIRADS5. EVEN BEFORE BIOPSY
Could aid mammogram in young,dense and breast prosthesis patients, and should be evaluated in other clinical scenarios as a Neoadyuvant Monitoring tool.
Finally as an early detecion procedure specifically in underdeveloped countries , could Triage in search of aggresive forms of the disease(T1,G2_G3). And aid Physical Exam of the Breast .
This site is dedicated to open mind Breast specialists ONLY .
¨EXPANDING OUR CURRENT COMPREHENSION, UNDERSTANDING AND APPROACH OF IMAGE AND DIAGNOSIS IN BREAST CANCER¨

lunes, 14 de octubre de 2013

DIRA can actually detect NON PALPABLE TUMORS 

That is a FACT

The "Correct" Political Speach at least in the Developing World ; prohibits :

to ACCEPT :

THAT : 
1.INCIDENCE AND
2. MORTALITY
are in an steady rise  and :


There is  NO PLAN OR STATISTIC PROJECTION TO REVERSE THESE  TRENDS . or these  Numbers to  CHANGE.

At least get them smaller. 

Question : 

1. Don´t you think it is time to try something else?
Awareness 
Breast Self Exam 
High Quality  Certified Clinical Breast Exam
Ultrasound and 
Digital Infrared Image

If we add all their capabilities they can actually help and detect . 

If you doubt it at all ........ I am 

At your service : 
emartindelcampo@yahoo.com 

lunes, 30 de septiembre de 2013

Making BETTER SENSE ......Digital Infrared Analysis and Specialized Breast Clinical Examination


Low income and resources country are recommended by the 

WORLD HEALTH ORGANIZATION 
that Breast Clinical Exam is a potential aid to downstage current local statistics..

Imagine this : Specialized Trained Hands AIMING where a Metabolical Image tells them to...

Here is the Message , clear and simple:

 if you can see go for the red area , if you don´t go where Warmer is felt. 



Now , it is logical , it does not fight the system and can actually HELP.

Would you forward the IDEA????

jueves, 26 de septiembre de 2013

BIRADS III , to be or not to be , a little hand where weakness exist




BIRADS III , see it for yourself:?
IVa or II








Add metabolic Information : 
Digital Infrared Analysis


Metabolic Assimetry is rapidly oriented to the left side



Highest Metabolical area is defined


And coincidental with the " BIRADS III "

Final Pathological Report :

Invasive Ductal Carcinoma .......

Makes me wonder , if it is logical and even physiological it could easily help where Morphology is UNCLEAR , NOT DEFINED , DOUBTFUL or MISDIAGNOSE...

Don´t you think so

Bye....

jueves, 5 de septiembre de 2013

Dense Breast Aid , SIMPLE AND EASY

Simple and easy there is no doubt and Standards are Changing and including by LAW the comment that includes BREAST DENSITY .

Dense breast tissue  not only is at  risk for more active tissue , but it is obviously a 
VISUAL Obstacle for Xray definition.

Even Clinically suspicious as the following case are reported  surprisingly as totally benign : BIRADS I 





 Morphological complement with Ultrasound clearly defines the even palpable nodule , great complement fortunately , enough for clinical decision making ........

Complementary Digital Infrared Image were these:


 Basal Frontal 



Basal Oblique Right


 Basal Oblique Left  Views


Functional Frontal 


Functional Right Oblique


Functional Left Oblique 


Close up.

COMMENT :

For me there is no DOUBT , Dense Breasts cannot rely only on Mammography , I am guessing everyone agrees.

Complementary procedures are obviously Needed.

Ultrasound when clinically evident is great.

"Infrared when clinically ASYMPTOMATIC , could help guide ULTRASOUND and define :

SUBCLINICAL POSITIVE BREAST CARCINOMAS"
 

EMC

And you can quote me on that ........

So here is the thing : around 30-40 percent of cases are diagnosed in women 45 years or younger , population defined radiologically as Possible DENSE BREAST .....

That is why even after 40 MILLION mammograms in  the US every year 20-30 percent are clinically evident.

And will be , if we do not try anything else...

To include an adaptative strategy for non INVASIVE or  IONIZING Screening in these women that are not candidates for Mammography or Have an anatomical BARRIER for Xrays.

It not only MAKES SENSE but it is a true LOGICAL POSSIBILITY.

Think about it and SMILE.

Welcome to open your minds and eyes.....

I think you should give it a try....

See you.

domingo, 14 de julio de 2013

Secondary Metachronic Invasive Ductal Carcinoma 23 Years After

Hi , it is me again.

Breast Cancer Survivor Women have  an increased risk for developing a secondary or metachronic breast cancer either in the same gland or in the opposite one.

It has been calculated around 5-10% and it would be progressively higher as time and age goes by.

This week I attended a 65 year old woman , that when she was 42 she had LEFT Stage III Breast Cancer ....... as she managed to survived after complete treatment she has been then under follow up.

LAST YEAR AUGUST 2012 She said to feel an small asymptomatic irragularity less than 1 cm in her inner quadrant of her remaining RIGHT breast and went for her annual Mammography with these images reported :

 Cefalo Caudal View and Close Up , a single Macrocalcification is seen in the INNER QUADRANTS

Slight density near it.


Medio Lateral Oblique View , moderate density , the same macrocalcification and  scattered densities
Probably Benign Inflammatory Lymph Nodes


Close up : Macrocalcification associated density.

BACK THEN BIRADS II 

Radiologist had no clear information to recommend a COMPLEMENTARY procedure.

NOW IF YOU WERE HER BREAST SURGEON OR ONCOLOGIST WOULD YOU CONCUR?
Ultrasound was added and final report sent : 

Final Radiological Intepretacion was Compatible with Benign Fybroid , yet considering biopsy?

As a complementary procedure  I performed : 

Digital Infrared Images were taken with the standard protocol and interpretation , developed for the last 4 years:


Basal frontal view  , area of interest , upper inner quadrant is one or IR activity easily detected and coincident for clinical findings. Directly "sepaking" of inherent metabolic activity.




After cold stress or stimuli , the same area is defined clearly as the highest peak or IR summit of the right breast.

Demonstrating : that these area "refuses" to get colder and that is the area of highest infrared radiation emmisivity....

Patient was scheduled for total excision of the nodule , with a pathologic report in the OR : 

Invasive Carcinoma was diagnosed and as consented previously , Mastectomy was undertaken with Sentinel Lymph Node......

Final immunohystochemical results were realised with the following reports:



Solid Papillary Invasive Carcinoma , Grade 2 
Progesterone and Estrogen Receptors  +++
Ki 67 positive in about 20% of the neoplastic cells and 
Her 2 Neu Negativity.

Comments :Digital  IR Image can aid standard radiological , morphological procedures such as Mammography and Ultrasound.

Is safe and practical .

Gives useful information for the Breast Specialist (Oncologist or Breast  Radiologist)

And actually can be related not only to its invasivity but for METABOLICAL individual Characteristics , such as final IHQ results : Hormone Receptirs , Ki 67 and Her 2 neu.

Have a good one ......

lunes, 24 de junio de 2013

Digital Infrared Analysis of the Breast_Free and Available.

Breast Cancer ORDER is mantained by the evidence created during the last 40 years with Mammography.

Nobody denies its intrinsic value and strengths.

It is our primary language against the Common Enemy : Breast Cancer

Yet , to reach its ideal goals and current trends it involves a complicated network of :


  1. personal , 
  2. political , 
  3. cultural , 
  4. geographical and 
  5. economical interests around this sometimes regretfuly "fashion" topic.


(Specially sensitive and a super candidate for promotion and glamour.)

To affirm that ONLY mammography holds the truth is 

To deny that anything else can help , and sounds to me as a MONOPOLY ...........

A scientifically based evidence of the INFRARED analysis and Behaviour of those MALIGNANT potentially MORTAL types of BREAST CANCER  in my mind is not only necessary but an obligation.....for all 

Since current trends will  be of Tsunamic Proportions as some have already stated 

.....Advanced cases in the vast majority of countries will keep on rising if we follow the same recommendations.

I do not intend to set aside Mammography ...that is not only impossible but Stupid.

I simply would like to let you know that DIRA can be useful and as time goes by , more and more examples will join , more women will be helped and an specific nich for its use will rise.

Last of all : I think that DIRA should be FREE  or near to free and available only for Breast Cancer Specialists .

Have a great week------EMC

jueves, 20 de junio de 2013

Nanoparticles-Infrared Image-Excised MArgins in Breast Cancer.

Hi everybody , one of the most important problems that we as surgeons have in breast conserving surgery is being able to deliver : SAFE MARGINS.

This is generally achieved as a "BLIND" procedure and it is dependent of individual  clinical and surgical  expertise  in order to produce negative tissue inked margins in the final pathological report , some recommend at least 1 cm of safe distance... so 

QUESTION : Can we in the near Future have an available method that can help us assure this "safety" in margins ?

Recent efforts are being described that couple:


  1.  Nanoparticles associated with 
  2. CANCER SPECIFIC Antibodies 
  3. Nanoparticle excited physical properties  and  
  4. It corresponding image :
Here is an example and is reference ......

I believe : 

"In the near future we will have the Technology by the association of Nanoparticles , monoclonal antibodies and the digital infrared image or another physical and visual intrinsic characteristic , which : 

WILL OFFER in vivo A VISUAL AID FOR THE SURGEON to produce safe margins in breast  conserving surgery ."EMC

Have a great day : 



(A) Schematic representation of nanoparticle communication to achieve amplified tumor targeting. Tumor-targeted signaling nanoparticles (blue) broadcast the tumor location to the receiving nanoparticles (red) present in circulation. (B) Shown are the harnessing of the biological cascade to transmit and amplify nanoparticle communication and the molecular signaling pathway between the signaling and receiving components. (C) Thermographic images of the photothermal NRs with heating. Seventy-two hours after NR or saline injection, mice were co-injected with FXIII-NWs and untargeted control-NWs, and their right flanks were broadly irradiated (top). Twenty-four hours post-irradiation, whole-animal fluorescence imaging revealed the distribution of the receiving nanoparticles (bottom). (D) Amplified tumor therapy with communicating nanoparticles. Tumor volumes following a single treatment with the communicating nanoparticle systems and controls. Reproduced with permission from ref :

 von Maltzahn G, Park JH, Lin KY, Singh N, Schwöppe C, Mesters R. et alNanoparticles that communicate in vivo to amplify tumour targetingNat Mater. 2011;10:545-52



This is another example with Fluorescent propierties...... 

Assessing Breast Cancer Margins Ex Vivo Using Aqueous Quantum-Dot-Molecular Probes
International Journal of Surgical Oncology
Volume 2012 (2012), Article ID 861257, 12 pages
doi:10.1155/2012/861257

miércoles, 29 de mayo de 2013

BIRADS III THERE SHOULD BE NO DOUBT AT ALL .....

Hi again :

Just Now I received an interesting clinical case , which I would Like to SHARE:

  1. FEMALE
  2. 45 years of age.
  3. First Birth at 17
  4. Positive Breast Feeding
  5. 8 Years with Oral Contraception
  6. Last Mammography 18 months.(REPORTED AS NORMAL BIRADS II ) 
  7. I week of Left Mastalgia and other minimal symptoms .
  8. Non identified Palpable Lesion on either Breast 
  9. Axilla : Undetermined 1 cm palpable Lymph Node on the left side. 

REMEMBER : "No radiological exams at all with the following Infrared Images" : 

 I will talk you through them: 



Basal Anterior View : 
Obvious Left Assimetry 
Enhanced Left Vascular Network
Irregular Left Mammary Fold
Single Upper Quadrant (12hrs) Line B on the Left Side.
Slightly Retracted Left Nipple....



Non of the previous findings on the Right...



Oblique View of the Left Breast , notice how entangled is the vascular network....




Physiological or Post  Cold Stress Challenge View:
Normal Right Breast cools down
Abnormal metabolic and Vascular Left Changes are enlightened.
Single Hiperthermia on the Left.

INFRARED ANALYSIS HARBORS :

  1. POSITIVE and NEGATIVE PREDICTIVE VALUES FOR DETECTED LESION
  2. METABOLIC BEHAVIOUR OF A  DETECTED LESIONS
  3. CAN STABLISH A RISK FOR FUTURE CANCER SPECIALLY IN FAMILIAL CASES AS THIS PATIENT IS. 
  4. CAN MONITOR EACH BREAST AS AN INTERVAL PROCEDURE.
"For me there is no doubt at all , Digital Infrared Analysis of the Breast holds an evident truth to be rediscovered by Breast specialists , hopefuly radiologists and Oncologists." EMC.

BIRADS III PLUS A POSITIVE METABOLICAL EXAMINATION SHULD PROMPT THE NEED FOR BIOPSY.

(And you can quote me on that)

Keep posted : ANATOMICAL OR MORPHOLOGICAL IMAGES will arrive soon.

My prediction : Positive Case for Breast Carcinoma , Invasive i would say.

"Prediction is often  confused with witchery , specially when the language is UNKNOWN......"

Lets see what happens...................

June 3rd 2013 .
Patient arrived with the following Mammographical and Ultrasound Images:

 Just to point out credibility , done last week and  45 years of age .........

Standard Oblique views , there is a density assimetry in the left breast with a single possibly benign calcification , no architectural distorsion or spiculated lesion.  Inflammatory axillary lymph Nodes. 


Close Up............. density becomes more evident right?


Calls my attention a single Level 1 Lymph node , which has higher   density in  it´s hilium......makes me wonder now....


 Cefalo Caudal Views , subtle central and inner density assimetry in the left breast with the same calcification , a little loss of the retromammary space 

Complementary Ultrasound , plus doppler : 

 I WILL QUOTE : " Left breast with a higher echogenicity , diffuse , with some microcysts and ductal dilations , 
 Elastography showed : left associated  mixed regions  some with a higher or more "solid" nature....

Now here comes UNCERTAINTY : BIRADS III

Standards of care demand a 6 month follow up

Lets BEND the rules , since Clinical knowledge comes from the sum of all previous cases...

I recommended no matter what happens after antiinflammatory treatment and antibiotic  to perfom CBC , Coagulation , and glucose tests. 

And after reviewing the results , i will schedule a Biopsy with a trucut.....

OBVIOUS 2 POSSIBILITIES:

MASTITIS vs Breast Carcinoma possibly T4d : inflammatory.

What do you THINK ? .............well:

"Infrared images are intended ONLY for Breasts Specialists , Breast Cancer Treatment is responsability ONLY for Oncologists.
Detection , Diagnosis and Treatment action depends entirely from : Evidence , History , Experience and a "different sense of feeling" only reserved for those Real Clinitians..........EMC"

(the ones that do not rely only in what they were told , those who  challenge with patience and good intention.... ) 





jueves, 23 de mayo de 2013

Is an Infrared Analysis of the Breast a complementary procedure?

SIMPLE :

If an Infrared Analysis of the Breast is an approved  Complementary procedure , then why don't we use it as SUCH?

ANSWER : NOT A SINGLE RADIOLOGIST ( except in Brasil ) has been trained or  INTERESTED in it  and as consequence the vast majority of Oncologists worldwide........


THE TRUTH : There are some BIRADS III that eventually turn into a positive cancer cases

                         BIRADS IV is way TOO tricky and HOLDS LOW SPECIFICITY.

                         And BIRADS 0 obviously needs SOME help.


Infrared Analysis HOLDS a physical and Biological MEANING , NEW evidence is  waiting to be built by EXPERTS in Breast Diseases , not in "alternative" health providers.

Seems logical to me and to you?



lunes, 13 de mayo de 2013

Is Mammography an Stereotyped Procedure?

Good Morning , I woke up this morning with this question:

Is mammography an stereotype behavior or medical , radiological procedure?

I was taught that it is our better weapon against Breast Cancer.
I was taught that chances of surviving depend ONLY in is detection Capabilities.
I was taught it should be done annually starting age at 40 .
I was taught it lowered by 30 % mortality rates.
I was taught never to question or challenge this concepts.

BUT

Is it really our best weapon when IT SAVES In situ lesions never to develop clinical signs or even influence mortality?
Not to mention over diagnosis and over treatment ....
Does surviving breast cancer Excludes then our current BETTER Treatments?
What about women 40 years and younger? And how about evidence against Annual vs BIANNUAL?
And  starting until 50 (normal risk)
Was it really 30% reduction in mortality or closer to 10%?

I think we Should we Challenge stereotypes and prove them wrong (when they are ) , and accept ADJUNCTIVELY WITH THE SATNDARDS OF CARE  some "old"  but 

  • logical , 
  • physical , 
  • reproductible , 
  • and methodical with a possible use , for a Better Detection , Less false positive Biopsies and help current recommended procedures.


Stereotype means : "SOLID IMPRESSION"

I believe we are entitled to rearrange strategies based on facts and evidenced associated to specific real human environments and scenarios....

" Not everything that shines is gold, is it? " EMC

Good day.

lunes, 29 de abril de 2013

Raise your hand?



Positive Breast Cancer all of them 

NON PALPABLE :











It May sound ridiculous , but some IR specific patterns actually mean :

INVASIVE BREAST CANCER...........

These could Help  : 

DETECTION . DIAGNOSIS or TREATMENT and even FOLLOW UP-

Keep it up.....it really does not matters at all how you identify a Breast Cancer if you actually can , right?

I Challenge this little evidence to be proved or revoked..........who will raise his or her hand?